Molecular heterogeneity of midbrain dopaminergic neurons--Moving toward single cell resolution.
Identifieur interne : 000643 ( Main/Exploration ); précédent : 000642; suivant : 000644Molecular heterogeneity of midbrain dopaminergic neurons--Moving toward single cell resolution.
Auteurs : Angela Anderegg [États-Unis] ; Jean-Francois Poulin [États-Unis] ; Rajeshwar Awatramani [États-Unis]Source :
- FEBS letters [ 1873-3468 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- genetics : Parkinson Disease.
- metabolism : Dopaminergic Neurons, Mesencephalon, Parkinson Disease.
- pathology : Mesencephalon, Parkinson Disease.
- Animals, Genetic Heterogeneity, Humans, Single-Cell Analysis, Transcriptome.
Abstract
Since their discovery, midbrain dopamine (DA) neurons have been researched extensively, in part because of their diverse functions and involvement in various neuropsychiatric disorders. Over the last few decades, reports have emerged that midbrain DA neurons were not a homogeneous group, but that DA neurons located in distinct anatomical locations within the midbrain had distinctive properties in terms of physiology, function, and vulnerability. Accordingly, several studies focused on identifying heterogeneous gene expression across DA neuron clusters. Here we review the importance of understanding DA neuron heterogeneity at the molecular level, previous studies detailing heterogeneous gene expression in DA neurons, and finally recent work which brings together previous heterogeneous gene expression profiles in a coordinated manner, at single cell resolution.
DOI: 10.1016/j.febslet.2015.10.022
PubMed: 26505674
Affiliations:
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xml:lang="en">Molecular heterogeneity of midbrain dopaminergic neurons--Moving toward single cell resolution.</title><author><name sortKey="Anderegg, Angela" sort="Anderegg, Angela" uniqKey="Anderegg A" first="Angela" last="Anderegg">Angela Anderegg</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Poulin, Jean Francois" sort="Poulin, Jean Francois" uniqKey="Poulin J" first="Jean-Francois" last="Poulin">Jean-Francois Poulin</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Awatramani, Rajeshwar" sort="Awatramani, Rajeshwar" uniqKey="Awatramani R" first="Rajeshwar" last="Awatramani">Rajeshwar Awatramani</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center for Genetic Medicine, Northwestern University, Chicago, IL 60611</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">FEBS letters</title><idno type="eISSN">1873-3468</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Dopaminergic Neurons (metabolism)</term><term>Genetic Heterogeneity</term><term>Humans</term><term>Mesencephalon (metabolism)</term><term>Mesencephalon (pathology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Single-Cell Analysis</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Mesencephalon</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mesencephalon</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Heterogeneity</term><term>Humans</term><term>Single-Cell Analysis</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since their discovery, midbrain dopamine (DA) neurons have been researched extensively, in part because of their diverse functions and involvement in various neuropsychiatric disorders. Over the last few decades, reports have emerged that midbrain DA neurons were not a homogeneous group, but that DA neurons located in distinct anatomical locations within the midbrain had distinctive properties in terms of physiology, function, and vulnerability. Accordingly, several studies focused on identifying heterogeneous gene expression across DA neuron clusters. Here we review the importance of understanding DA neuron heterogeneity at the molecular level, previous studies detailing heterogeneous gene expression in DA neurons, and finally recent work which brings together previous heterogeneous gene expression profiles in a coordinated manner, at single cell resolution.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Anderegg, Angela" sort="Anderegg, Angela" uniqKey="Anderegg A" first="Angela" last="Anderegg">Angela Anderegg</name></region><name sortKey="Awatramani, Rajeshwar" sort="Awatramani, Rajeshwar" uniqKey="Awatramani R" first="Rajeshwar" last="Awatramani">Rajeshwar Awatramani</name><name sortKey="Poulin, Jean Francois" sort="Poulin, Jean Francois" uniqKey="Poulin J" first="Jean-Francois" last="Poulin">Jean-Francois Poulin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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